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Purpose and Aims

ENPEN brings together professionals from a variety of clinical specialties (paediatrics, neurology, internal medicine, microbiology and virology), from public health institutions, national reference laboratories and academia. Our main aim is to raise professional awareness for more effective detection, to develop diagnostics and to guide surveillance activities. We also aim to share data on outbreaks and emerging enteroviruses.

The European Non-Polio Enterovirus Network has been established under the auspices of the European Society for Clinical Virology. ENPEN brings together professionals from a variety of clinical specialties (paediatrics, neurology, internal medicine, microbiology and virology), from public health institutions, national reference laboratories and academia, from over 20 European countries. Our main aim is to raise professional awareness for more effective detection, to develop diagnostics and to guide surveillance activities. We also aim to share data on outbreaks and emerging enteroviruses.

ENPEN has been a very productive and active group; related publications can be found from below:

  1. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe 
  2. A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
  3. Recommendations for the nomenclature of enteroviruses and rhinoviruses

Many ENPEN members have also contributed to the following publications and data sharing:

  1. Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study.

Bubba L, Broberg EK, Jasir A, Simmonds P, Harvala H; Enterovirus study collaborators.
Lancet Infect Dis. 2019 Dec 20. pii: S1473-3099(19)30566-3. doi: 10.1016/S1473-3099(19)30566-3.

  1. Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20. Midgley SE, Benschop K, Dyrdak R, Mirand A, Bailly JL, Bierbaum S, Buderus S, Böttcher S, Eis-Hübinger AM, Hönemann M, Jensen VV, Hartling UB, Henquell C, Panning M, Thomsen MK, Hodcroft EB, Meijer A.Euro Surveill. 2020 Jan;25(2). (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976881).

In 2021, a new paper with the title Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe has been published. To read the full publication, click here.

In October 2021, the paper with the title European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe was published. Find here the link to read the new open access paper.

For details and contact

Visit the ENPEN website: http://www.enpen.net/home